Recombinant:Article Title: Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer.
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Mouse monoclonal anti-MLH1 Ventana Cat#790-5091 Rabbit monoclonal anti-MSH6 Ventana Cat#790-5092 Mouse monoclonal anti-MSH2 Ventana Cat#790-5093 Mouse monoclonal anti-PMS2 Ventana Cat#790-5094 Rabbit polyclonal anti-DR5 Abcam Cat#ab8416 Rabbit monoclonal anti-DR5 Cell Signaling Technology Cat#69400 Mouse monoclonal anti-DR5 Abmart Cat#MN00822 Rabbit monoclonal anti-Ki67 Cell Signaling Technology Cat#9027 Rabbit monoclonal anti-CDX2 Cell Signaling Technology Cat#12306 Mouse anti-CKpan ZSGB-Bio Cat#ZM-0069 Rabbit anti-CK20 ZSGB-Bio Cat#ZA-0574 Mouse monoclonal anti-β-Catenin BDbiosciences Cat#610153 Rabbit polyclonal anti-CDK4 Proteintech Cat#11026-1-AP Rabbit polyclonal anti-AKT(Ser473) Cell Signaling Technology Cat#9272 Rabbit monoclonal anti-Phospho-AKT (Ser473) Cell Signaling Technology Cat#4060 Rabbit monoclonal anti-ERK1/2 Cell Signaling Technology Cat#4695 Rabbit monoclonal anti-Phospho-ERK1/2 (Thr202/Tyr204) Cell Signaling Technology Cat#4370 Rabbit monoclonal anti-p38 Cell Signaling Technology Cat#8690 Rabbit monoclonal anti-Phospho-p38 (Thr180/Tyr182) Cell Signaling Technology Cat#4511 Rabbit polyclonal anti-Bcl-2 Affinity Cat#AF6139 Rabbit polyclonal anti-Retinoblastoma Affinity Cat#AF6103 Rabbit polyclonal anti-Phospho-Retinoblastoma (Ser780) Affinity Cat#AF3103 Rabbit polyclonal anti-Cyclin D2 Affinity Cat#AF5410 Rabbit polyclonal anti-Notch1 Proteintech Cat#10062-2-AP Rabbit polyclonal anti-Notch2 Proteintech Cat28580-1-AP Rabbit polyclonal anti-Notch3 Proteintech Cat#55114-1-AP Rabbit monoclonal anti-GAPDH Cell Signaling Technology Cat#5174 Biological samples CRC patient samples This paper Table S1 Chemicals, peptides, and recombinant proteins SNS-032 Selleck Cat#S1145 Roscovitine Selleck Cat#S1153 Flavopiridol Selleck Cat#S1230 JNJ-7706621 Selleck Cat#S1249 PHA-793887 Selleck Cat#S1487 AT7519 Selleck Cat#S1524 BS-181 HCl Selleck Cat#S1572 BMS-265246 Selleck Cat#S2014 AZD5438 Selleck Cat#S2621 R547 Selleck Cat#S2688 PHA-767491 Selleck Cat#S2742 (Continued on next page) e1 Cell Reports Medicine 6, 102158, June 17, 2025 OPEN ACCESS .. REAGENT or RESOURCE SOURCE IDENTIFIER Milciclib Selleck Cat#S2751 Dinaciclib Selleck Cat#S2768 Wogonin Selleck Cat#S4743 NU2058 Selleck Cat#S5316 NU6027 Selleck Cat#S7114 TG003 Selleck Cat#S7320 LDC000067 Selleck Cat#S7461 ML167 Selleck Cat#S7509 LY2857785 Selleck Cat#S7511 THZ1 2HCl Selleck Cat#S7549 SU9516 Selleck Cat#S7636 Ro-3306 Selleck Cat#S7747 Purvalanol A Selleck Cat#S7793 Kenpaullone Selleck Cat#S7917 LDC4297 Selleck Cat#S7992 P276-00 Selleck Cat#S8058 K03861 Selleck Cat#S8100 ON123300 Selleck Cat#S8161 MSC2530818 Selleck Cat#S8387 Senexin A Selleck Cat#S8520 Skp2 inhibitor C1 Selleck Cat#S8652 Atuveciclib Selleck Cat#S8727 SEL120 Selleck Cat#S8840 CVT-313 Selleck Cat#S6537 Bohemine Selleck Cat#S6531 THZ531 Selleck Cat#S6595 SGC-GAK-1 Selleck Cat#S6710 AX-024 HCl Selleck Cat#S6727 BI-1347 Selleck Cat#S1058 Indirubin-3 ′ -monoxime Selleck Cat#S2009 XL413 Selleck Cat#S7547 MK-8776 Selleck Cat#S2735 G1T38 Selleck Cat#S8568 Abemaciclib mesylate Selleck Cat#S7158 Ribociclib Selleck Cat#S7440 Palbociclib Selleck Cat#S4482 Trilaciclib Selleck Cat#S8389 FLI-06 Selleck Cat#S7399 polybrene Polyscience Cat#23966-1 puromycin Beyotime Cat#ST551 SDS Lysis Buffer Beyotime Cat#P0013G PMSF Solarbio Cat#P0100 Phosphatase inhibitor cocktail Beyotime Cat#P1081 Anti-fade Mounting Medium with DAPI Beyotime Cat#P0131 Critical commercial assays Agilent SureSelect Human All Exon V6 Agilent Cat#5190-8864 Agilent SureSelectXT Mouse All Exon library Agilent Cat#5190-4643 CellTiter-Glo® Luminescent Cell Viability Assay Promega Cat#G7573 (Continued on next page) Cell Reports Medicine 6, 102158, June 17, 2025 e2 OPEN ACCESS
Article Title: Combined therapy with DR5-targeting antibody-drug conjugate and CDK inhibitors as a strategy for advanced colorectal cancer
Article Snippet: .. REAGENT or RESOURCE SOURCE IDENTIFIER Antibodies Mouse monoclonal anti-MLH1 Ventana Cat#790-5091 Rabbit monoclonal anti-MSH6 Ventana Cat#790-5092 Mouse monoclonal anti-MSH2 Ventana Cat#790-5093 Mouse monoclonal anti-PMS2 Ventana Cat#790-5094 Rabbit polyclonal anti-DR5 Abcam Cat#ab8416 Rabbit monoclonal anti-DR5 Cell Signaling Technology Cat#69400 Mouse monoclonal anti-DR5 Abmart Cat#MN00822 Rabbit monoclonal anti-Ki67 Cell Signaling Technology Cat#9027 Rabbit monoclonal anti-CDX2 Cell Signaling Technology Cat#12306 Mouse anti-CKpan ZSGB-Bio Cat#ZM-0069 Rabbit anti-CK20 ZSGB-Bio Cat#ZA-0574 Mouse monoclonal anti-β-Catenin BDbiosciences Cat#610153 Rabbit polyclonal anti-CDK4 Proteintech Cat#11026-1-AP Rabbit polyclonal anti-AKT(Ser473) Cell Signaling Technology Cat#9272 Rabbit monoclonal anti-Phospho-AKT (Ser473) Cell Signaling Technology Cat#4060 Rabbit monoclonal anti-ERK1/2 Cell Signaling Technology Cat#4695 Rabbit monoclonal anti-Phospho-ERK1/2 (Thr202/Tyr204) Cell Signaling Technology Cat#4370 Rabbit monoclonal anti-p38 Cell Signaling Technology Cat#8690 Rabbit monoclonal anti-Phospho-p38 (Thr180/Tyr182) Cell Signaling Technology Cat#4511 Rabbit polyclonal anti-Bcl-2 Affinity Cat#AF6139 Rabbit polyclonal anti-Retinoblastoma Affinity Cat#AF6103 Rabbit polyclonal anti-Phospho-Retinoblastoma (Ser780) Affinity Cat#AF3103 Rabbit polyclonal anti-Cyclin D2 Affinity Cat#AF5410 Rabbit polyclonal anti-Notch1 Proteintech Cat#10062-2-AP Rabbit polyclonal anti-Notch2 Proteintech Cat#28580-1-AP Rabbit polyclonal anti-Notch3 Proteintech Cat#55114-1-AP Rabbit monoclonal anti-GAPDH Cell Signaling Technology Cat#5174 Biological samples CRC patient samples This paper Table S1 Chemicals, peptides, and recombinant proteins SNS-032 Selleck Cat#S1145 Roscovitine Selleck Cat#S1153 Flavopiridol Selleck Cat#S1230 JNJ-7706621 Selleck Cat#S1249 PHA-793887 Selleck Cat#S1487 AT7519 Selleck Cat#S1524 BS-181 HCl Selleck Cat#S1572 BMS-265246 Selleck Cat#S2014 AZD5438 Selleck Cat#S2621 R547 Selleck Cat#S2688 PHA-767491 Selleck Cat#S2742 (Continued on next page) e1 Cell Reports Medicine 6, 102158, June 17, 2025 Article ll OPEN ACCESS .. REAGENT or RESOURCE SOURCE IDENTIFIER Milciclib Selleck Cat#S2751 Dinaciclib Selleck Cat#S2768 Wogonin Selleck Cat#S4743 NU2058 Selleck Cat#S5316 NU6027 Selleck Cat#S7114 TG003 Selleck Cat#S7320 LDC000067 Selleck Cat#S7461 ML167 Selleck Cat#S7509 LY2857785 Selleck Cat#S7511 THZ1 2HCl Selleck Cat#S7549 SU9516 Selleck Cat#S7636 Ro-3306 Selleck Cat#S7747 Purvalanol A Selleck Cat#S7793 Kenpaullone Selleck Cat#S7917 LDC4297 Selleck Cat#S7992 P276-00 Selleck Cat#S8058 K03861 Selleck Cat#S8100 ON123300 Selleck Cat#S8161 MSC2530818 Selleck Cat#S8387 Senexin A Selleck Cat#S8520 Skp2 inhibitor C1 Selleck Cat#S8652 Atuveciclib Selleck Cat#S8727 SEL120 Selleck Cat#S8840 CVT-313 Selleck Cat#S6537 Bohemine Selleck Cat#S6531 THZ531 Selleck Cat#S6595 SGC-GAK-1 Selleck Cat#S6710 AX-024 HCl Selleck Cat#S6727 BI-1347 Selleck Cat#S1058 Indirubin-3′-monoxime Selleck Cat#S2009 XL413 Selleck Cat#S7547 MK-8776 Selleck Cat#S2735 G1T38 Selleck Cat#S8568 Abemaciclib mesylate Selleck Cat#S7158 Ribociclib Selleck Cat#S7440 Palbociclib Selleck Cat#S4482 Trilaciclib Selleck Cat#S8389 FLI-06 Selleck Cat#S7399 polybrene Polyscience Cat#23966-1 puromycin Beyotime Cat#ST551 SDS Lysis Buffer Beyotime Cat#P0013G PMSF Solarbio Cat#P0100 Phosphatase inhibitor cocktail Beyotime Cat#P1081 Anti-fade Mounting Medium with DAPI Beyotime Cat#P0131 Critical commercial assays Agilent SureSelect Human All Exon V6 Agilent Cat#5190-8864 Agilent SureSelectXT Mouse All Exon library Agilent Cat#5190-4643 CellTiter-Glo® Luminescent Cell Viability Assay Promega Cat#G7573 (Continued on next page) Cell Reports Medicine 6, 102158, June 17, 2025 e2 Article ll OPEN ACCESS
|
Proteintech is a verified supplier 